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Consil® Bioglass® is a commercially available bioactive glass formulation previously shown in clinical studies to support osteogenesis and the repair of bony defects in dogs and cats. Previous in vitro studies confirm that Consil® particles are able to bond directly with bone while promoting...
A tissue‐engineered bone graft should imitate the ideal autograft in both form and function. However, biomaterials that have appropriate chemical and mechanical properties for grafting applications often lack biological components that may enhance regeneration. The concept of adding proteins...
This study describes a novel method of calcium phosphate cement reinforcement based on infiltrating a pre‐set cement with a reactive polymer and then cross‐linking the polymer in situ. This method can be used to reinforce 3D calcium phosphate cement scaffolds, which we demonstrate using...
In this work, nanofibre membranes have been produced from polyvinyl alcohol (PVA), polycaprolactone (PCL), polyacrylonitrile (PAN), poly (vinylidene fluoride‐co‐hexafluoropropene) (PVdF‐HFP), and polymer blend of PAN and polyurethane (PEU) using an electrospinning technique, and wound...
Last trends in Biomaterials focus the mimic of cellular environments capable to control cellular responses. Epidermal growth factor (EGF) is a pleiotropic cytokine known to regulate cell proliferation, differentiation, and death. This study aims to optimize the immobilization of EGF on...
Despite a wide range of available sources for bone repair, significant limitations persist. To bioengineer bone, we have previously transferred adenovirus‐mediated human BMP‐2 gene into autologous bone marrow stromal cells (MSC). We have successfully repaired large, full thickness, cranial...
Current strategies to enhance gene transfer have focused on the development of vectors to increase the efficiency of DNA delivery. However, the extracellular matrix and microenvironment have a profound impact on numerous cellular activities including spreading and proliferation; two processes...
In tissue engineering, the resorbable aliphatic polyester poly(L‐lactide) (PLLA) is used as scaffolds in bone regeneration. Copolymers of poly(L‐lactide)‐co‐(ε‐caprolactone) (poly(LLA‐co‐CL)) and poly(L‐lactide)‐co‐(1,5‐dioxepan‐2‐one) (poly(LLA‐co‐DXO)), with...
A variety of surface modifications have been tested for the enhancement of screw fixation in bone, and locally delivered anti‐osteoporosis drugs such as bisphosphonates (BP) are then of interest. In this in vivo study, the impact of surface immobilized BP was compared with systemic BP delivery...
Bone repair and regeneration is one of the most extensively studied areas in the field of tissue engineering. All of the current tissue engineering approaches to create bone focus on intramembranous ossification, ignoring the other mechanism of bone formation, endochondral ossification. We...
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