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The macrophage has a major role in normal wound healing and the reparative process around implants. Murine macrophage‐like cells RAW 264.7 were used to investigate the effect of titanium surfaces on macrophage activation and secretion of proinflammatory cytokines (interleukin (IL)‐1β,...
To optimize polymer‐conjugated drugs as a polymeric drug delivery system, it is essential to design polymeric carriers with tissue‐specific targeting capacity. Previously, we showed that polyvinylpyrrolidone (PVP) was the most suitable polymeric carrier for prolonging the blood‐residency of...
We developed a novel method of evaluating biofilm architecture on a synthetic material using green fluorescent protein‐expressing Escherichia coli and red fluorescence staining of exopolysaccharides. Confocal laser scanning microscopy observation revealed the time course of the change in the in...
Metallic medical devices undergo degradation in vivo and the degradation products affect the chemistry and biological responses of cells and tissues in the immediate vicinity. The responses vary with the metal and cell type. In the current study, we examined the effects of several metals on a...
Pathologic calcification is the leading cause of the clinical failure of glutaraldehyde‐fixed bovine pericardium used in bioprosthetic valves. A novel surface modification of glutaraldehyde fixed bovine pericardium was carried out with high molecular weight hyaluronic acid (HA). HA was...
We developed poly(propylene fumarate)/poly(lactic‐co‐glycolic acid) (PPF/PLGA) blend microspheres and investigated the effects of various processing parameters on the characteristics of these microspheres. The advantage of these blend microspheres is that the carbon–carbon double bonds...
Poly‐L‐lactic acid (PLLA) is a widely used promising material for surgical implants such as tissue‐engineered scaffolds. In this study, we aimed to determine the in vivo effect of PLLA plates on the cellular function of subcutaneous tissue in the two mouse strains, BALB/cJ and SJL/J, higher...
Control of the cell surface allows modulation of the cell's biological response, producing practical applications and satisfying scientific interests. Consequently, to meet such goals and interests, diverse approaches were developed in cell surface engineering techniques. Poly(ethylene glycol)...
Thrombosis is an initiating reaction to vascular injury that follows the placement of vascular devices. Platelets play a crucial role in this response. Their interaction with endovascular devices is not solely a function of device properties, but a multifaceted response dependent on several...
Osteogenic cells from newborn rat calvariae were cultured on titanium surfaces on which cell orientation could be manipulated. Substrata included smooth surfaces and substrata with smooth regions (gaps) flanked by grooves of 47‐μm pitch and 3‐, 10‐, or 30‐μm depth. Orientation angles of...
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