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Objectives To assess the impact of a multifaceted educational intervention concerning treatment of infections in the nursing home setting. Methods We used a cluster randomized controlled trial. Fifty-eight nursing homes in Sweden were randomly assigned either to educational intervention or...
Objectives To analyse the susceptibility pattern of a collection of Alternaria spp. clinical isolates. Methods The antifungal susceptibilities of 35 isolates identified by means of sequencing the internal transcribed spacer region of rDNA were analysed by European Committee on Antimicrobial...
Background Temocillin, a β-lactam stable against most β-lactamases (including extended-spectrum β-lactamases (ESBLs) and derepressed AmpC cephalosporinases (dAmpC)), has been suggested as an alternative to carbapenems when Pseudomonas can be excluded. Aims To assess temocillin clinical and...
Everyone prescribing antibiotics should consider both their clinical and public health responsibilities. The objective should be to provide optimal patient care while at the same time seeking to minimize selective pressure that may result in the emergence and spread of antibiotic resistance. To...
Objectives This proof-of-concept study aimed to identify whether mutations considered not yet relevant for drug resistance (but located at key drug-resistance positions) can act as ‘sentinels’ of minority resistant variants in HIV-1 drug-naive patients. Methods We focused our attention on...
Objectives It is difficult to draw conclusions about the prudence of antibiotic use in different hospitals by directly comparing usage figures. We present a patient case-mix adjustment model of antibiotic use to rank hospitals while taking patient characteristics into account. Patients and...
Objectives Butyrate is a short-chain fatty acid that is produced by several human commensal bacteria, such as Clostridium and Lactobacillus species. Butyrate is also known to inhibit histone deacetylase. In this study we assessed the antifungal activity of sodium butyrate (SB) against the human...
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