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We propose a possible mechanism for the telomere shortening signal. The suggested solution of this as yet unsolved enigmaâhow cell senescence is causally linked to telomere shorteningâis based on a "fountain theory" of modulation of eukaryotic gene expression, in which gene expression...
A traditional herb ("Toki-shakuyaku-san" or TJ-23) has been reported to cause clinical improvement in patients with Alzheimer's dementia. To investigate possible neuronal mechanisms, we looked at its effect on cholinergic functions in the cortex, hippocampus, striatum, midbrain, pons-medulla...
The comparative neurochemical characteristics of brain and liver membranes of senescence-accelerated mice, prone (SAMP1) and senescence-accelerated mice, resistant (SAMR1) strains were evaluated using males and females of several ages. Abnormal N -methyl- D -aspartic acid (NMDA) binding and...
We studied age-related changes in the noradrenergic function in the pancreatic islets of streptozotocin diabetic male Wistar rats. Blood glucose, norepinephrine content, noradrenergic receptor binding, and cyclic adenosine monophosphate (cAMP) content were analyzed in the pancreatic islets of...
Aging is the accumulation of changes that increase the risk of death. The major contributors after age 28 years are the endogenous chemical reactions that, collectively, produce aging changes that exponentially increase the chances for disease and death with age. These reactions constitute the...
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