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Epidemiological studies have demonstrated that hypercholsterolemia is a significant risk factor for Alzheimer's disease (AD). The mechanism by which increased cholesterol may contribute to AD is unknown. However, as the generation and accumulation of the amyloid A \beta peptide in the brain...
The National Institute on Aging (NIA) of the National Institutes of Health (NIH) has stimulated many recent landmark advances in the understanding and treatment of Alzheimer's disease (AD) and related dementing disorders. This progress is due in part to an extramural network of AD Centers (ADCs)...
The familial Alzheimer's disease gene products, presenilin-1 and presenilin-2 (PS1 and PS2), are involved in amyloid \beta -protein precursor processing (A \beta PP), Notch receptor signaling, and programmed cell death. However, the molecular mechanisms by which presenilins regulate these...
The nuclei of the olivary complex are involved in regulating motor movements and in motor learning. Aging is characterized by a progressive accumulation of lipofuscin while the number of olivary neurons is unchanged. It is not known whether neuronal loss occurs in the olivary nucleus during...
The assessment of protein or amino acid variations across evolution allows one to glean divergent features of disease-specific pathology. Within the Alzheimer's disease (AD) literature, extensive differences in A \beta processing across cell lines and evolution have clearly been observed. In the...
The most consistent diagnostic neuropathological lesion in Alzheimer's disease (AD) is the senile plaque of which the 4 kD amyloid- \beta (A \beta ) peptide is the major proteinaceous component. In this study cortical A \beta levels were immunochemically measured in 70 post-mortem human brains...
The cdc2/cyclin B1 kinase is absent from neurons that are terminally differentiated. However, unscheduled activation of Cdc2/cyclin B and accumulation of mitotic phosphoepitopes have been described in degenerating neurons of Alzheimer's disease (AD), and their appearance precedes hallmark lesion...
It is widely accepted that A \beta plays a pivotal role in the pathogenesis of Alzheimer's disease (AD) (27). Attention has been focused mainly on how extracellular A \beta exerts its effects on neuronal cells (7,11,16,32). However, neuronal degeneration from an accumulation of intracellular A...
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