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Internucleosomal DNA fragmentation, which is a well-known feature of apoptosis but not an absolute criterion for identifying apoptosis (1), has often been observed in the brain tissue of Alzheimer's disease (AD). However, classical apoptotic morphology such as nuclear condensation, membrane...
The abnormal form of the prion protein has increased resistance to protease digestion and is insoluble in non-ionic detergents. The normal prion protein is modified by the non-obligatory addition of two N-linked glycans. One pathogenic mutation, Thr to Ala at residue 183 of the human prion...
Epidemiological studies have indicated that non-steroidal anti-inflammatory drugs (NSAID) may have some therapeutic effect in Alzheimer's disease (AD) and experimental studies have shown that microglia activation by Aâ-peptide (Aâ) can be influenced by NSAIDs. We analysed 42 clinically and...
Our first project aimed to determine the average values of Fe and Zn in normal German human brain (5 individuals, 10 brain parts). Determinations were carried out by instrumental neutron activation analysis in Berlin. Quality control measurements were performed using National Institute of...
The aim of the present study was to evaluate the acetylcholinesterase activity in the brain of adult gerbils (Meriones unguiculatus) treated with aluminum. AlCl3 x 6H2O was given "per os" in the amount of 3.7 g/kg body weight. The animals were killed 24, 48, 72 and 96 hours after the treatment....
Recent studies have shown that the missense mutation in presenilin-1 (E280A) increases deposition of amyloid-â (Aâ(1-42/43)) producing severe cerebellar pathology. Although Aâ has been involved as a neurotoxic peptide, its role in neuronal loss in PS-1 (E280A) patients has not yet been...
Treatment of cultured neurons with â-amyloid (Aâ) evokes multiple consequences, including calcium influx, production of reactive oxygen species (ROS), hyperphosphorylation of tau. Which of these events is the major cause of Aâ-induced neurodegeneration has been the subject of controversy. We...
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