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It is logical to assume that the efficacy of an aerosolized drug should be related to the local airway dose. To test this assumption, it is necessary to have some index of the distribution of deposited drug within the airway and a measure of efficacy. However, most studies, in which the regional...
There is a mandatory need for effortless drug administration to young children since the prevalence among them of recurrent wheezing is 15-20%. It is becoming increasingly evident that many of these children respond dramatically well to beta2-agonists and topical steroids; accordingly this...
A compressed air source is needed to run a jet nebulizer; its operating pressure affects the aerosol flow through the nebulizer, the quantity of drug and/or solution leaving the nebulizer, and the droplet size. With increasing pressure, the output (gravimetric change during nebulization) will...
Powder inhalers rely on the patient's inspiratory flow for delivery and aerosolization of the medicament. Different inhalers offer different resistances to inspiration through the device. The flow rate attained by a patient depends on the effort expended and on the air flow resistance of the...
The main function of a jet nebulizer is to aerosolize the contained liquid. The primary generation point is the orifice where the compressed air expands and increases in velocity. At this point the expanding air induces an underpressure and liquid is sucked up to the air orifice where it meets...
Solutions and suspensions of drugs are used widely in the pharmaceutical industry for production of dosage forms for different routes of administration; for example, oral, parenteral and inhalation. Pharmaceutical solutions and suspensions might appear to be simple formulations but they can...
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