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Deposition in mouth and throat of 3.6 Î¼m (aerodynamic diameter) monodispersed Teflon particles labelled with 111 In was studied in agroup (n=29) of mild to moderately severe asthmatics. The particles were inhaled at 0.5 1/sec. with maximally deep inhalations. Immediately after the inhalation...
In the very near future, the CFC manufacturers are going to be obliged to stop their production as a a result of the "Montreal protocole on substances that deplete the ozone layer". The replacement of these propellants by other fluorinated ones will be possible as soon as their lack of toxicity...
Mathematical models which have been developed to predict the deposition of particles in the conducting airways of the lung require simplified anatomical models of the dimensions and geometry of the bronchial airways. In order to produce valid deposition predictions, the computed volumes of the...
Because basic aerosol research has suggested that the addition of propylene glycol to nebulizer solutions enhances the nebulizer output, especially of particles of "respirable" size less than 5Î¼, radioaerosol techniques were used to determine if adding propylene glycol would improve aerosol...
Inhaled particles deposited in the intrapulmonary conducting airways may be retained considerably longer than 24 hours. We studied structure and function of the 2âphase coating (gel, sol) of the wall of these airways with respect to retention and clearance of such particles. The airway...
The dose in the respiratory tract which causes an effect depends critically on airway geometry, ventilatory parameters, particle characteristics and clearance and retention kinetics. Most often, effects of inhaled compounds are characterized by "exposure-response" relationships rather than by...
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