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In order to answer the question “what research remains to be done?” we review the current state of the art in pharmaceutical aerosol deposition modeling and explore possible in vivo– in vitro correlations (IVIVC) linking drug deposition in the human lung to predictions made using in vitro...
Deposition and clearance studies are used during product development and in fundamental research. These studies mostly involve radionuclide imaging, but pharmacokinetic methods are also used to assess the amount of drug absorbed through the lungs, which is closely related to lung deposition....
The 1000 Years of Pharmaceutical Aerosols Conference convened posing the question; “what remains to be done?” When applying this question to the topic of inhaler devices, two hugely different perspectives could be taken. On the one hand, it could be argued that because there is an array of...
Significant advances have been made in the last 50 years in developing safe and efficacious aerosol formulations for pulmonary delivery. The key to future innovation may lie at the interface between biology and particle engineering. Improved understanding of biological processes including...
Although there is a modest body of literature on the absorption of inhaled pharmaceuticals by normal lungs and some limited information from diseased lungs, there is still a surprising lack of mechanistic knowledge about the details of the processes involved. Where are molecules absorbed, what...
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