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This JAMA Patient Page discusses the US Preventive Services Task Force’s recommendations on screening for adolescent idiopathic scoliosis.
This Medical Letter review summarizes the mechanism of action and adverse effects of combination lesinurad, an uric acid transporter 1, and allopurinol, a xanthine oxidase inhibitor, for treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels...
This study describes hospital participation and dropout in the Centers for Medicare & Medicaid Innovation’s Bundled Payments for Care Improvement Initiative, which allows hospitals and practices to retain savings if they meet quality targets.
ImportanceAdolescent idiopathic scoliosis (AIS), a spinal curvature of 10° or more, is the most common form of scoliosis, with a prevalence of 1% to 3%. Curves progress in approximately two-thirds of patients with AIS before skeletal maturity, and large curves (>50°) may be associated with...
Key PointsQuestionDoes idalopirdine, a selective 5-hydroxytryptamine-6 receptor antagonist, improve cognitive change in patients with mild to moderate Alzheimer disease when added to cholinesterase inhibitors?
FindingsIn 3 randomized clinical trials that included a total of 2525 patients with...
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