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Key PointsQuestionDoes 2 years of grass pollen sublingual immunotherapy reduce symptoms after nasal allergen challenge at 3-year follow-up (1 year after discontinuation of treatment)?
FindingsIn this randomized clinical trial of 106 adults, 2 years of treatment with sublingual immunotherapy,...
This study describes the 2-year outcomes for participants of a randomized trial of mindfulness-based stress reduction vs cognitive behavioral therapy or usual care for adult participants with chronic low back pain.
This Viewpoint discusses potential threats to public health that arise from provisions of the 2016 21st Century Cures Act that allow drug manufacturers to use surrogate measures of safety and that encourage the US Food and Drug Administration to emphasize speed over science in the drug approval...
This Medical Letter review summarizes background and prescribing information about combination sofosbuvir and velpatasvir, a recently approved oral treatment for all hepatitis C virus genotypes.
This Viewpoint discusses examples of intentional equivocation (hedging) in clinical practice guidelines from professional societies and proposes that less certain or actionable recommendations be removed from guidelines and published in other formats.
Key PointsQuestionWhat is the effectiveness of a scalp cooling device in preventing alopecia in women with breast cancer undergoing neoadjuvant or adjuvant chemotherapy?
FindingsIn a randomized clinical trial of 182 women with breast cancer receiving chemotherapy with a taxane, anthracycline, or...
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