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Graeme M. Clark and colleagues describe the evolving science of cochlear implants and the histopathology associated with a patient who had his implant removed when it failed in 1983 and again in 1998. Dr Clark has been awarded the 2013 Lasker-DeBakey Clinical Medical Research Award for his...
ImportanceThree clinical decision rules were previously derived to identify patients with headache requiring investigations to rule out subarachnoid hemorrhage.
ObjectiveTo assess the accuracy, reliability, acceptability, and potential refinement (ie, to improve sensitivity or specificity) of...
ImportanceKnee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity.
ObjectiveTo determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and...
ImportanceHypertension is common among people older than 65 years, affecting nearly two-thirds of men and three-fourths of women by age 75 years. Treatment goals and medication selection for this population may differ from those for younger patients.
ObjectiveTo discuss the presentation,...
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