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Surgery for Lumbar Spinal Stenosis In a retrospective cohort analysis of Medicare claims data, Deyo and colleagues Article examined trends in lumbar spinal stenosis surgery and the association of complications, postoperative mortality, and resource use with surgical complexity. The authors found...
In Reply: We agree with Dr Vosk that RCTs can be considered reliable only if properly designed, conducted, analyzed, and interpreted, a fundamental principle that applies equally to observational studies. Observational studies can test large effects, but RCTs of adequate size, dose, and duration...
A team of scientists has found that a novel agent is effective against H5N1 avian influenza virus, including oseltamivir-resistant strains (Kiso M et al. PLoS Pathog. 2010;6:e1000786). The neuraminidase inhibitor R-125489 and its prodrug CS-8958 have previously shown potent activity against...
Misspelling Changing Meaning: In the Literatim entitled “Abraham Flexner and His Remarkable Report on Medical Education: A Century Later” published in the March 3, 2010, issue of JAMA (2010;303:888-890), “contract” was misspelled as “contact,” changing the meaning of a sentence. The last...
A genome-wide association study by US researchers has led to the discovery of the first major gene site responsible for the severe food allergy eosinophilic esophagitis (EoE), a disorder that features the accumulation of eosinophils in the esophagus (Rothenberg ME et al. Nat Genet....
Long before he sat down to compose the dramas that have enlightened and haunted audiences by the millions, Eugene O’Neill contracted tuberculosis. Like most serious illnesses, it forever changed him. In O’Neill's case, the infection was a transformation that enabled him to divine his genius and...
For the first time, the US Food and Drug Administration (FDA) has expanded the indications of a statin therapy that targets certain asymptomatic individuals. How this will play out in the clinical setting remains to be seen. On February 8, the FDA announced that rosuvastatin is now indicated for...
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