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ALLERGIC asthma is the most common immunologic pulmonary disease. However, a variety of other inflammatory and genetic lung diseases have immunopathogenic mechanisms. Cystic fibrosis (CF), granulomatous, and interstitial lung disease are important representatives of these immune-mediated...
THE NERVOUS system traditionally has been considered an "immunologically privileged" site that is shielded by functional or anatomic barriers from systemic immune responses.1 However, several lines of experimental and clinical evidence suggest that immune responses can affect and even take place...
TWO EVENTS revolutionized the field of immunohematology: the discovery of the ABO blood group system by Karl Landsteiner in 1900 and the development of the Coombs' test in 1945. These observations resulted in the improved safety and success of blood transfusions.
Approximately 2% of hospitalized...
BLISTERING diseases of the skin are common. Causes include infectious agents, allergic drug reactions, contact dermatitis, and autoimmune diseases. This report will describe autoimmune blistering diseases.
Physicians should suspect an autoimmune bullous disease when there is no clear history of...
SINCE the earliest descriptions of the immune system, the ability of an individual to react to a wide variety of foreign and endogenous antigens, while not responding to one's own self, has intrigued researchers.
The first descriptions of autoimmune phenomena in the early 1900s aroused...
AS PREDICTED by Salvaggio and Austen1 in the final chapter of the 1987 edition of the JAMA primer, many contributions to medicine continue to emerge from research in the field of allergy and immunology.1-4 Precise and sensitive immunologic laboratory techniques, including enzyme-linked...
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