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A 43-year-old woman with severe coronary artery disease and hyperapobetalipoproteinemia was heterozygous for an abnormal Msp I apolipoprotein B (APOB) gene fragment because of the absence of the Msp I site around codon 4046 in exon 29 of the APOB gene. Using the polymerase chain reaction...
An error occurred in the Original Contribution entitled "Allelic Loss in Colorectal Carcinoma," published in the June 2 issue of The Journal (1989;261:3099-3103). The title should have read as follows: "Clinical and Pathological Associations With Allelic Loss in Colorectal Carcinoma."
To the Editor.—
As project director for the Department of Defense's civilian external peer review program, I was pleased to note your November 11th publication of both the preliminary article by Mayer and colleagues1 as well as Dr Kelly's2 astute editorial. When I was first called regarding...
Are patients concerned about going to a physician who is infected with human immunodeficiency virus (HIV) or one who is treating HIV-infected patients? To answer these questions, we surveyed a nationwide sample of 2000 interviews (response rate, 75%). Forty-five percent of all respondents...
THE DOOR that leads to true gene therapy appears to have been opened a little wider by the finding that tumor-infiltrating lymphocytes armed with a marker gene can survive in a patient for at least 19 days.
With this preliminary finding, the National Institutes of Health (NIH) (Bethesda, Md)...
A 16-MONTH-OLD child was considered to have human immunodeficiency virus (HIV) infection at 4 months of age when she developed acute interstitial pneumonia that was documented by open lung biopsy to be caused by Pneumocystis carinii. The patient's mother was known to be HIV...
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