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"The A he goal is to alleviate human disease—and to do it with a power that has heretofore been reserved for the gods."
This statement describing gene therapy is from the introduction to an award-winning series of articles published in March in the Chicago Tribune. The introductory installment...
It's been four years since the National Cancer Institute (NCI) formally announced that it was launching a long-range cancer chemoprevention program. Since then, the institute has launched 26 clinical trials, and backed them with about $27 million in funding annually. The designs—and preliminary...
We agree with Dr Fuchs that a 1.9 mm Hg reduction in diastolic blood pressure might not mean much for a particular patient, but an average drop of that size in a population of patients with hypertension could have large benefits. Such a drop normally comes from large reductions in...
To the Editor.—
Keeler et al1 in their article state that "differences of 1.9 mm Hg in diastolic blood pressure... are important—they translate into differences of 5% to 8% in the probability of dying in the next year." As a clinician, I am very skeptical that a reduction in diastolic blood...
To the Editor.—
The clinical value of a laboratory test depends on more than just a statistically significant difference between two test groups. Grimm et al1 may have overemphasized the prognostic importance of the white blood cell count for coronary heart disease. The unwary may be misled...
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