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Following a Food and Drug Administration review of three major phase IV studies involving from 7,607 to 22,653 persons, it was determined that none of the studies resulted in the detection of new adverse drug reactions (ADRs). For two of the three drugs studied, new ADRs were identified after...
This multiauthor text (32 authors, 554 pages) has a clearly stated objective: "to bridge the gap between the theory of management and... application... in the clinical laboratory." It also has a clearly defined audience: "the individual who finds himself in a supervisory capacity for the first...
To the Editor.—
I would like to comment on the article by Swerdloff and Boyers entitled "Evaluation of the Male Partner of an Infertile Couple: An Algorithmic Approach" (1982; 247:2418). The authors clearly stress the importance of the thorough examination of the male partner of the infertile...
We have read Dr Bass' letter and offer the following comments. The date of admission for our patient (April 4, 1980) was obviously before the Food and Drug Administration's release of cefotaxime for noninvestigational use and, thus, our reference to the need for informed consent. Our...
The effect of sexual activity on vaginal atrophy was investigated in a group of 52 postmenopausal women (mean age, 57 years). Subjects were divided into two groups: sexually active (intercourse frequency, three or more times monthly) and sexually inactive (intercourse frequency, less than ten...
Dr Schwarzstein has raised a number of interesting points in his letter in response to our article, "Evaluation of the Male Partner of an Infertile Couple: An Algorithmic Approach."
We are of common mind regarding the importance of a careful history and physical examination. The...
ALLOCATION AND RATIONING OF HEALTH CARE RESOURCES
Of all the resource-shortage crises this nation is expected to confront in the future, the problem of resource distribution is likely to be most acute and problematic in medicine.23,29,123 Persons will be recognized as in need of, and then...
Dr Rosch is correct in asserting that evidence of increased incidence of CHD in the presence of certain characteristics (risk factors) does not justify, in itself, the conclusion that they are causative factors. As he recognizes, clinical trials such as the MRFIT are necessary to...
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