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Two semisynthetic derivatives of the plant genus Podophyllum have received high marks in clinical trials on patients with small-cell lung cancer.
One of the two chemically similar compounds, etoposide (VP16), has recently been recommended for approval as an anti-cancer agent by the Food and Drug...
BEFORE the development of genetic engineering technologies, it was questionable whether microorganisms that theoretically could be produced by application of such techniques would legally qualify for patent protection.
Section 101 of the Patent Act, 35 USC §101 (1976), authorizes the...
Use of combination oral contraceptives (OCs) has been reported to decrease a woman's risk of endometrial cancer developing. To investigate this issue further, we analyzed data from a multicenter, population-based, case-control study—the Cancer and Steroid Hormone Study conducted by the Centers...
Primary care can be offered to individual patients by anyone, but the purpose of my editorial was to caution physicians not experienced in the use of immunosuppressive compounds alone or in combination from applying such dramatic treatments without benefit of consultation. I would...
To the Editor.—
I have just read "A Fable of the Clinic" in the Nov 12 issue of The Journal (1982;248:2321).
It is most saddening to see that the author had to withhold his or her name. Thus, what happened is less a fable and much a tragedy.
The problem addressed by the fable is that of the...
To the Editor.—
I read the recent letter entitled "Sinus Standstill Following Lidocaine Administration" by Antonelli and Bloch (1982;248:827). Although the authors stated that "lidocaine does not depress the sinus node at the conventional therapeutic dose," we reported in 1973 the first...
The three most recent submissions to JAMA by Leonard B. Berman, MD, reveal a great deal about this physician, scientist, teacher, and philosopher who died Jan 24 of renal carcinoma a week after his 59th birthday.
First is his learned and highly readable discussion for JAMA's CONTEMPO issue of...
Screening an at-risk population for early-stage lung cancer—a practice that has been declared ineffective by the American Cancer Society (ACS) because studies have not shown that it lowers mortality rates—nonetheless received emphatic support at the recent annual meeting of the Radiological...
Many physicians know the frustration of trying to help stroke victims or patients with other severe neurological injuries to regain some semblance of normal activity. Even for physical rehabilitation experts, this is a demanding challenge. But one physician's use of hypnosis with such patients...
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