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Severe hemodilution used in open-heart surgery
Hematocrits of patients in Boston series were reduced to as low as 10%; some of these also underwent deep hypothermia and cardiac arrest
Severe hemodilution of the patients' own blood permitted cardiac repair in two Jehovah's Witness children...
A patient with the classical findings of thrombotic thrombocytopenic purpura (TTP) was treated with heparin sodium, splenectomy, and highdose steroids without appreciable benefit. In the face of continued deterioration, hemodialysis was instituted. This was followed by clinical improvement and...
In 50 hyperlipidemic patients who responded to clofibrate during a three-month trial period, the medication was continued for six to eight years. Eight of the subjects had essential hypercholesterolemia. The remainder had elevations of both the cholesterol and triglyceride levels. Normalization...
Six patients developed acute cholecystitis while recovering from multiple injuries. Five had fractures of one or more bones, and none had intraabdominal trauma. None of the patients had previous symptoms suggestive of gallbladder or other gastrointestinal disease. The postinjury course was...
It was by chance that I became involved in 1946 in the clinical evaluation of antihypertensive agents. After World War II, I had returned to Boston to complete my residency training in internal medicine and to work in hemodynamics research with Robert Wilkins at the Massachusetts Memorial...
The problem of gene structure and coding was exciting while it lasted. The story of the past two eventful decades, including my own contributions, has been well told,1-3 and need not be repeated here. But molecular genetics, pursued to ever lower levels of organization, inevitably does away with...
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