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ImportanceOndansetron hydrochloride use in children with gastroenteritis is increasing rapidly; however, little is known about its impact on outcomes.
ObjectiveTo determine whether increasing emergency department ondansetron use has resulted in a reduction in intravenous rehydration rates....
ImportanceChronic fatigue syndrome (CFS) is a disabling condition with unknown disease mechanisms and few treatment options.
ObjectiveTo explore the pathophysiology of CFS and assess clonidine hydrochloride pharmacotherapy in adolescents with CFS by using a hypothesis that patients with CFS have...
ImportanceA better understanding of the cause of obesity is a clinical priority. Obesity is highly heritable, and specific genes are being identified. Discovering the mechanisms through which obesity-related genes influence weight would help pinpoint novel targets for intervention. One potential...
ImportanceCritical congenital heart disease (CCHD) was added to the Recommended Uniform Screening Panel for Newborns in the United States in 2011. Many states have recently adopted or are considering requirements for universal CCHD screening through pulse oximetry in birth hospitals. Limited...
ImportanceIdentifying early markers of future obesity risk can help target preventive interventions. Several studies have shown that a heartier appetite in infancy is a risk factor for more rapid weight gain, but to date no investigations have been able to rule out familial confounding....
Birth defects are a leading cause of infant morbidity and mortality worldwide. The vast majority of birth defects are nonsyndromic, and although their etiologies remain mostly unknown, evidence supports the hypothesis that they result from the complex interaction of genetic, epigenetic,...
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