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This Viewpoint explores the consequences of COVID-19–related social distancing on health behaviors that may result in better or worse outcomes for individuals with cancer.
Key PointsQuestionWhat is the clinical utility of genomic profiling for patients with advanced solid tumors?
FindingsIn this cohort study of 1015 patients who underwent integrative genomic profiling, a high rate of pathogenic germline variants and a subset of patients who derive substantial...
Key PointsQuestionHow do estradiol levels in male patients with hormone receptor–positive breast cancer change after 3 months of therapy with aromatase inhibitor (AI) plus gonadotropin-releasing hormone analogue (GnRHa) compared with GnRHa plus tamoxifen or tamoxifen alone?
FindingsA total of 52...
Key PointsQuestionDoes triple-negative breast cancer (TNBC) subtyping inform on chances of achieving a pathologic complete response (pCR) and on the potential benefits of adding carboplatin to standard neoadjuvant chemotherapy?
FindingsThis prespecified secondary analysis of a randomized...
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