1 - 10 of 13 articles
This cross-sectional study uses pharmacovigilance data to investigate the occurrence of pancytopenia among patients with cancer treated with poly(adenosine diphosphate–ribose) polymerase inhibitors and examines the clinical features of pancytopenia related to these drugs.
Key PointsQuestionWhich is the optimal endocrine partner (fulvestrant vs letrozole) for cyclin-dependent kinase 4 and 6 inhibitor palbociclib in previously untreated, endocrine-sensitive, hormone receptor–positive, ERBB2-negative advanced breast cancer?
FindingsIn this randomized, open-label,...
Key PointsQuestionCan the McGill Interactive Pediatric OncoGenetic Guidelines (MIPOGG) differentiate between children with cancer who have a low or high likelihood of having a cancer predisposition syndrome?
FindingsIn phase 1 of this predictive accuracy study, MIPOGG facilitated earlier...
This Viewpoint examines the role of adjuvant chemotherapy, radiotherapy, or combined treatment for stage 1 pancreatic ductal adenocarcinoma.
ImportanceIn the past decade, ERBB2 (formerly HER2)–directed antibody-drug conjugates (ADCs) have substantially changed treatment of both advanced and early-stage ERBB2-positive breast cancer. Novel conjugates are now showing activity in trials of other ERBB2-associated tumors, leading to the...
ImportanceThe COVID-19 pandemic has had consequences for patients with cancer worldwide and has been associated with delays in diagnosis, interruption of treatment and follow-up care, and increases in overall infection rates and premature mortality.
ObservationsDespite the challenges experienced...
This Viewpoint discusses the value of patient time in cancer care and considers its importance in existing oncology frameworks and clinical decision-making.
Key PointsQuestionWhat is the nodal recurrence rate in patients with clinically node-positive (cN1) breast cancer treated with sentinel lymph node biopsy (SLNB) alone after neoadjuvant chemotherapy (NAC)?
FindingsIn this cohort study of 610 patients with cN1 breast cancer, among 234 consecutive...
Key PointsQuestionWas the differential adoption of neoadjuvant chemotherapy by US cancer centers for advanced-stage epithelial ovarian cancer associated with differences in overall survival?
FindingsIn this difference-in-differences comparative effectiveness research study that included 39 299...
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