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This phase 3 randomized clinical trial assesses whether dasatinib given at 80 mg/m2 is more effective than imatinib mesylate at 300 mg/m2 to improve event-free survival in children with Philadelphia chromosome–positive acute lymphoblastic leukemia.
Key PointsQuestionWill the observed shortened life expectancy of adult survivors of childhood cancer lengthen over time given improvements in treatment and care?
FindingsUsing a simulation model–based approach, this study estimates that children who received a diagnosis of and were treated for...
This cost-utility analysis assesses the value of tisagenlecleucel compared with current standard care for tisagenlecleucel-eligible pediatric patients with acute lymphoblastic leukemia.
This review summarizes current clinical challenges and discusses available models for risk stratification in the context of smoldering multiple myeloma.
Key PointsQuestionWhat is the most effective treatment strategy after a period of first-line induction therapy for patients with metastatic colorectal cancer?
FindingsThis systematic review and network meta-analysis of 12 relevant randomized clinical trials comprising 5540 patients with...
This Viewpoint discusses the challenges in providing oncologic care for an increasing number of patients and suggests potential solutions to improve clinicians’ efficiency and productivity.
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