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Key PointsQuestionWhat are the advantages of total neoadjuvant therapy (preoperative systemic chemotherapy in combination with chemoratiation [TNT]) compared with the traditional approach of preoperative chemoradiation and postoperative adjuvant chemotherapy in patients with locally advanced...
ImportanceSarcopenia (low muscle mass), poor muscle quality (low muscle radiodensity), and excess adiposity derived from computed tomography (CT) has been related to higher mortality in patients with metastatic breast cancer, but the association with prognosis in patients with nonmetastatic...
This Viewpoint evaluates whether there is benefit for medical centers to advertise the opportunity for clinical trial participation.
ImportanceThe debate about the role of the Food and Drug Administration (FDA) in the regulation of laboratory-developed tests (LDTs) has focused attention on the analytical performance of all clinical laboratory testing. This study provides data comparing the performance of LDTs and FDA-approved...
This analysis of health claims data from 3 large nationwide insurers examines changes in oral anticancer medication use, out-of-pocket spending, and total health plan spending associated with adoption of state parity laws.
This cohort study examines the reliability and potential utility of 2 commercially available liquid biopsy assays for reported mutations in cell-free DNA.
This Viewpoint examines the evidence supporting the efficacy of intraoperative radiation therapy compared with other treatment modalities for patients with early-stage breast cancer.
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