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Key PointsQuestionWhich modern immuno-oncology agents reach the threshold for bonus points for durable survival in the American Society of Clinical Oncology (ASCO) value framework for cancer care?
FindingsIn this analysis of 23 indications for 6 immuno-oncology agents approved by the US Food and...
Key PointsQuestionWhat is the role of deficient DNA mismatch repair (MMR) in stage III colon cancer in the era of standard FOLFOX (folinic acid, fluorouracil, and oxaliplatin) adjuvant chemotherapy?
FindingsThis pooled multivariable analysis of data from 2 randomized clinical trials revealed...
This study examines the lack of race-adjusted measurements for renal function in eligibility criteria for participation of black men in prostate cancer trials.
Key PointsQuestionWhat is the rate of cardiovascular adverse events (CVAE) among patients receiving carfilzomib for multiple myeloma?
FindingsIn this systematic review and meta-analysis of 24 prospective clinical trials including 2594 patients, all-grade and high-grade CVAE were seen in 18.1%...
ImportanceThere have been substantial improvements in the early detection, treatment, and survival from cancer in the United States, but it is not clear to what extent patients with different types of health insurance have benefitted from these advancements.
ObjectiveTo examine trends in cancer...
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