1 - 10 of 27 articles
ImportanceSeveral surrogates for prostate cancer–specific mortality satisfying the Prentice criteria exist, but whether these are surrogates for all-cause mortality, and how their performance compares, is unknown.
ObjectiveTo ascertain and compare the performance of 4 candidate surrogates...
A major challenge in value-based health care is the lack of standardized health outcomes measurements, hindering optimal monitoring and comparison of the quality of health care across different settings globally. The International Consortium for Health Outcomes Measurement (ICHOM) assembled a...
ImportancePatients with breast cancer (BrCa) brain metastases (BrM) have limited therapeutic options. A better understanding of molecular alterations acquired in BrM could identify clinically actionable metastatic dependencies.
ObjectiveTo determine whether there are intrinsic subtype...
This Viewpoint discusses the significance of investing billions of dollars in genomic sequencing and the implications of finding a hereditary mutation in patients with metastatic cancer using next-generation sequencing.
This Viewpoint describes the disproportionate domestic impact on rural and inner-city citizens of the United States caused by the recent immigration and travel ban, and seeks to affirm physicians’ commitment to more and not less diversity and inclusion.
ImportanceIndividualized cancer treatment, tailored to a particular patient and the tumor’s biological features (precision oncology), requires a detailed knowledge of tumor biology. Biological characterization is typically performed on biopsy material, but this approach can present challenges...
Key PointsQuestionWhat is the causal relevance of telomere length for risk of cancer and non-neoplastic diseases?
FindingsIn this Mendelian randomization study, genetically longer telomeres were associated with higher odds of disease for 9 of 22 primary cancers tested but with reduced odds of...
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