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This secondary analysis of a randomized clinical trial examines whether a germline mutation in a microRNA-binding site in KRAS is a predictive biomarker of cetuximab response and altered immunity following radiotherapy and cisplatin treatment for head and neck squamous cell cancer.
ImportanceSeveral factors are associated with increased hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT), but no reliable risk score has been established to determine the individual risk for HCC recurrence.
ObjectiveWe aimed to develop and validate a Risk Estimation of...
Key PointsQuestionIn patients with cirrhosis at high risk for hepatocellular carcinoma (HCC), is surveillance for HCC with magnetic resonance imaging (MRI) superior to surveillance by ultrasonography (US)?
FindingsIn this prospective surveillance study of 407 patients with cirrhosis and a risk...
Key PointsQuestionUsing metaplastic breast cancer as a surrogate, is phosphoinositide 3-kinase (PI3K) pathway–directed therapy effective in the treatment of mesenchymal triple-negative breast cancer (TNBC)?
FindingsIn this cohort of patients with metaplastic TNBC, the combination of liposomal...
Key PointsQuestionWhat is the clinical effectiveness of dual-target inhibition of the MEK and AKT pathways as a treatment strategy for KRAS-mutant tumors compared with cytotoxic oxaliplatin plus fluorouracil (modified FOLFOX) chemotherapy?
FindingsIn this phase 2 randomized clinical trial,...
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