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ImportanceGlobular glial tauopathies (GGTs), as defined by a consensus study in 2013, belong to the group of frontotemporal lobar degenerations and expand the spectrum of glial-predominant neurodegenerative diseases. Three neuropathological subtypes of GGT (types I-III) are characterized by...
This cohort study examines Alzheimer disease symptoms and age at onset; changes in amyloid, tau, and neurodegeneration biomarkers; and topography of brain changes in adults with Down syndrome.
A 63-year-old man presented with a history of vomiting, hypertension, dyslipidemia, type 2 diabetes, dilated ischemic cardiomyopathy, alcohol use, and stroke; physical examination found appendicular dysmetria with truncal ataxia and downbeat nystagmus. Brain magnetic resonance imaging revealed a...
Key PointsQuestionWhat is the prognostic value of tau positron emission tomography (PET) for predicting cognitive decline across the clinical spectrum of Alzheimer disease?
FindingsIn this longitudinal, multicenter prognostic study including 1431 participants, baseline tau PET predicted change...
This essay discusses the journey of a surgical oncologist as she navigates her father’s diagnosis of amyotrophic lateral sclerosis as a physician and daughter in the face of evolving health care value.
Key PointsQuestionIs there a COVID-19–associated myopathy, and is it a viral or postviral phenomenon?
FindingsIn this case-control autopsy study, 26 of 43 individuals (60%) who had died with a diagnosis of COVID-19 showed signs of muscle inflammation, ranging from mild to severe inflammatory...
Key PointsQuestionAre rare pathogenic genetic variants associated with risk for sporadic moyamoya disease?
FindingsIn a genetic association study including a 24-proband discovery cohort and an 84-proband validation cohort of non–East Asian patients with moyamoya disease, whole-exome sequencing...
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