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Key PointsQuestionWhat is the relationship between the antidepressant effect of ketamine and ketamine dose and blood level, and is its antidepressant effect mediated by an effect on ventro-medial prefrontal cortical glutamate and glutamine or γ-aminobutyric acid response?
This cross-sectional study examines acyl-ghrelin levels in Pakistani adolescents who experienced severe trauma and have posttraumatic stress disorder (PTSD) compared with adolescents who have not experienced severe trauma.
Key PointsQuestionIs exposure to bisphenol A, a ubiquitous chemical of concern, associated with long-term risk of mortality?
FindingsIn a cohort study of 3883 adults in the United States, participants with higher urinary bisphenol A levels were at higher risk for death during approximately 10...
This randomized clinical trial assesses the comparative effectiveness of the Healthy Choices intervention when delivered in a clinic- vs home-based setting on medication adherence and alcohol use among youths and young adults living with HIV.
This diagnostic study investigates whether there are clinically significant differences between Snellen visual acuity examinations performed by a human vs a smart speaker.
Key PointsQuestionIn children with acute lymphoblastic leukemia receiving oral mercaptopurine, can an intervention consisting of education and daily text message reminders to prompt directly supervised therapy result in a higher proportion of patients with mercaptopurine adherence 95% or higher,...
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