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Lysosomal storage diseases (LSD) form a group of inherited metabolic disorders caused by dysfunction of one of the lysosomal proteins, resulting in the accumulation of certain compounds. Although these disorders are among first genetic diseases for which specific treatments were proposed, there...
Several reports demonstrated that mesenchymal stem cells (MSCs) might differentiate into smooth muscle cells (SMCs) in vitro and in vivo. It has been shown that myocardin protein is a strong inducer of smooth muscle genes and MSCs can differentiate into SMCs in response to transforming growth...
4‐Aminobiphenyl, a known carcinogen, has many environmental sources like cigarette smoke, industrial waste, and so forth. It can be metabolized to form a potent mutagen, N‐hydroxy‐N‐acetyl‐4‐aminobiphenyl (N‐OH‐AABP) that undergoes further processing to form electrophilic...
The suppressor of cytokine signalling (SOCS) box was first identified in the SH2‐containing SOCS box family (cytokine‐inducible SH2‐containing protein, SOCS1–7) and is a 40‐amino acid motif, which functions to recruit an E3 ubiquitin ligase complex consisting of the adapter proteins...
Phage display has identified the dodecapeptide YHWYGYTPQNVI (GE11) as a ligand that binds to the epidermal growth factor receptor (EGFR) but does not activate the receptor. Here, we compare the EGFR binding affinities of GE11, EGF, and their polyethyleneimine‐polyethyleneglycol (PEI‐PEG)...
Bruton agammaglobulinemia tyrosine kinase (BTK) is a key protein in the B‐cell receptor (BCR) signaling pathway and plays an essential role in the differentiation of B lymphocytes. X‐linked agammaglobulinemia (XLA) is a primary humoral immunodeficiency caused by mutations in the gene encoding...
Polyketides represent an important class of biologically active and structurally diverse compounds in nature. They are synthesized from acyl‐coenzyme A substrates by polyketide synthases (PKSs). PKSs are classified into three groups: types I, II, and III. This article introduces recent studies...
The plasma cholesterol‐reducing effect of phytosterols (PS) has been recognized in several studies, but the usefulness of PS in preventing coronary heart disease remains controversial, as some investigations claim that the high PS concentrations found in plasma and specific tissues are related...
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