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The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss‐of‐function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR‐95a, miR‐126,...
Members of the breast cancer 1 (BRCA1) carboxy‐terminal (BRCT) superfamily are involved in the cellular response to the DNA damage sensing and repair, as well as in the cell cycle control. All proteins are characterized by one or more BRCT domain(s), which provides a flexible framework...
The extracellular matrix (ECM) is a highly dynamic network of proteins, glycoproteins, and proteoglycans. Numerous diseases result from mutation in genes coding for ECM proteins, but only recently it has been reported that mutations in the fibronectin (FN) gene were associated with a human...
Recently, cytochrome P450 170A1 (CYP170A1) has been found to be a bifunctional protein, which catalyzes both monooxygenase activity and terpene synthase activity by two distinct active sites in the well‐established P450 protein structure. Therefore, CYP170A1 is identified clearly as a...
This review considers the use of yeasts to study protein moonlighting functions. The cases discussed highlight the possibilities offered by the well‐developed yeast genetics for the study of moonlighting mechanisms. The possibility to generate sets of mutants encoding different protein variants...
Complex cellular machines and processes are commonly believed to be products of selection, and it is typically understood to be the job of evolutionary biologists to show how selective advantage can account for each step in their origin and subsequent growth in complexity. Here, we describe how...
Previous deletion studies have suggested that Tyr306 has an important influence on the properties of protein phosphatase‐1 (PP1). To test this inference, we constructed three site‐directed mutants, PP1Y306A, PP1Y306K, and PP1Y306E. The specific activity of PP1Y306A was 3.5‐fold higher than...
Both Alzheimer's disease (AD) and almost every second case of frontotemporal lobar degeneration (FTLD) are characterized by the deposition of hyperphosphorylated forms of the microtubule‐associated protein tau in neurons and/or glia. This unifying pathology led to coining the umbrella term...
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug. Activation of platelets is therefore crucial for normal hemostasis. However, uncontrolled platelet activation may also lead to the formation of occlusive thrombi that can cause ischemic events. Platelets...
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