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Familial hypercholesterolaemia (FH) is a human inherited disorder of metabolism characterised by increased serum low‐density lipoprotein (LDL) cholesterol. It is caused by defects in the LDL‐receptor pathway that impair normal uptake and clearance of LDL by the liver. The commonest cause of...
Phenotypic switching and proliferation of vascular smooth muscle cells (VSMCs) are critical components in the development of many vascular proliferation diseases such as atherosclerosis and restenosis after percutaneous coronary interventions. Krüppel‐like factor 4 (KLF4) has been shown to...
Agonist‐selective signaling or ligand‐biased signaling of G protein‐coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current review...
Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c‐Myc. Alternatively they can negatively regulate ubiquitin‐dependent signalling cascades such as the...
The myriad of side effects that associate with morphine has been problematic in the clinical use to manage moderate to severe pain. It has been the holy grail of the pharmacologists to develop a compound, or treatment paradigm that could retain the analgesic effect of the drug as eliminating or...
Tbx2 is a member of the T‐box family of transcription factors that are crucial in embryonic development. Recent studies suggest that T‐box factors may also play a role in controlling cell cycle progression and in the genesis of cancer. Tbx2 has been implicated in several developmental...
Many cancer cells refractory to radiation treatment and chemotherapy proliferate due to loss of intrinsic programmed cell death (apoptosis) regulation. Consequently, the resolution of these cancers are many times outside the management capabilities of conventional therapeutics. We have developed...
trans‐Translation is a process which the bacterial cells apply to rescue the ribosomes that are arrested during the translation of damaged mRNA and to get rid of the mRNA and the product polypeptide. In the course of trans‐translation, the mRNA‐like domain of tmRNA replaces the nonstop...
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