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Model for verprolin function. See Verprolin: A Cool Set of Actin‐binding Sites and Some Very HOT Prolines by Munn and Thanabalu, pp. 707–712.
Peroxisomes play an important role in lipid metabolic pathways and are implicated in many human disorders. Their biogenesis has been studied over the last two decades using many uni and multi‐cellular model systems and many aspects of the mechanisms and proteins involved in peroxisome...
Spatiotemporal organisation of eukaryotic cells is established and maintained by the cytoskeleton, a highly dynamic and complex network of structural and signalling proteins. Many components of the cytoskeleton are functionally and structurally conserved between humans and yeast. Among these are...
In eukaryotic cells, the physical separation of the genetic material in the nucleus from the translation and signaling machinery in the cytoplasm by the nuclear envelope creates a requirement for a mechanism through which macromolecules can enter or exit the nucleus as necessary....
Mitochondrial uncoupling of oxidative phosphorylation may serve a variety of purposes such as the regulation of substrate oxidation, free radical production (a major by‐product of mitochondrial respiration) and ATP production and turnover. As regulators of energy expenditure and antioxidant...
Some archaea of the Euryarchaeota present a unique version of the Embden–Meyerhof pathway where glucose and fructose‐6‐phosphate are phoshporylated using ADP instead of ATP as the phosphoryl donor. These are the only ADP‐dependent kinases known to date. Although initially they were...
The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential...
Hepatitis C virus (HCV) is an enveloped positive‐strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral...
In the last few years dysregulated expression of the cell surface glycoprotein CUB domain‐containing protein 1 (CDCP1) has been associated with several cancers and this cell surface molecule has been recognized both as a tumor marker and as a potential target to disrupt progression of cancer....
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