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A single C/T difference between gene and cDNA within the 5′‐untranslated region of the wheat mtDNA‐encoded cox2 (cytochrome oxidase subunit 2) sequence catalyzed the discovery of C‐to‐U RNA editing in plant mitochondria by a group at Dalhousie University in Halifax, Nova Scotia (Covello...
Heme scavenging by plasma proteins, including serum albumin (SA), provides protection against free‐heme oxidative damage, limits access by pathogens to the heme, and contributes to iron homeostasis by recycling the heme iron. In turn, serum heme‐albumin (SA‐heme) acquires heme‐based...
The methionine salvage pathway, also called the 5′‐methylthioadenosine (MTA) cycle, recycles the sulfur of MTA, which is a by‐product in the biosyntheses of polyamine and the plant hormone ethylene. MTA is first converted to 5′‐methylthioribose‐1‐phosphate either by MTA...
For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNATrp gene showed that it is not able to decode the...
Dystroglycan (DG) is a membrane receptor belonging to the complex of glycoproteins associated to dystrophin. DG is formed by two subunits, α‐DG, a highly glycosylated extracellular matrix protein, and β‐DG, a transmembrane protein. The two DG subunits interact through the C‐terminal...
Uncoupling proteins (UCPs) belong to a family of mitochondrial carrier proteins that are present in the mitochondrial inner membrane. Genetic and experimental studies have shown that UCP dysfunction can be involved in metabolic disorders and in obesity. Uncoupling protein‐1 (UCP1; also known as...
Nuclear protein 1 (NUPR1) was originally identified as p8, a member of the family of HMG‐I/Y transcription factors induced in response to various cellular stressors. However, the signaling pathway underlying NUPR1 induction by cellular stresses remains to be established. In this study, we found...
It took several independent observations of C‐to‐T differences between genomic mtDNA sequences and corresponding complementary DNA (cDNA) sequences before RNA editing in plant mitochondria was accepted as a fact by the group at Tübingen and later Berlin (Hiesel et al., Science246 (1989)...
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