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The aggressive biological behavior of invasive and metastatic cancer is considered to be the most insidious and life‐threatening aspect for breast cancer patients. It is mostly the result of changes in many molecular characteristics of tumor cells, including alterations in gene expression and...
Chlorogenic acid (CGA) has been proved to be an activator of calcineurin (CN) in our previous research. In this study, the activation mechanism of CN by CGA was further explored. The results showed that although the purified CN was inactive in vitro if only Ca2+/calmodulin (CaM) existed without...
Recent progress in the understanding of the human dietary requirement for choline highlights the importance of genetic variation and epigenetics in human nutrient requirements. Choline is a major dietary source of methyl‐groups (one of choline's metabolites, betaine, participates in the...
Virus‐based gene therapy has advanced to clinical trials; however, this approach may result in serious adverse events including oncogenesis and the possibility of triggering fatal immune responses. Nonviral gene delivery approaches have a better safety profile, but their in vivo application has...
The aim of this study was to assess the in vitro anticandidal activity of Indole‐3‐carbinol (I3C) and its mode of action against Candida albicans. The results indicated that I3C exhibited candidacidal activity in an energy‐independent manner without hemolytic effect on human erythrocytes....
Calcineurin (CN) is the common receptor for two immunophilin‐immunosuppressant complexes, Cyp‐CsA and FKBP‐FK506. Calcineurin is composed of a catalytic subunit (CNA) and a regulatory subunit (CNB). CNA contains the catalytic domain and three regulatory domains: a CNB‐binding domain (BBH,...
The signaling networks that mediate cell growth, differentiation, and survival are dependent on complex metabolic and redox pathways. Metabolism of glucose through the pentose phosphate pathway (PPP) fulfills two unique functions: formation of ribose 5‐phosphate for the synthesis of...
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