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The rat organic anion transporter 3 (rOAT3) has recently been identified as the third isoform of the OAT family. The mechanisms that regulate rOAT3's functions remain to be elucidated. rOAT3 contributes for moving a number of negatively charged organic compounds between cells and their...
Thrombotic diseases such as heart attack and stroke remain a major health concern in the Western world despite existing anti‐thrombotic drugs. Current studies are revealing structure‐function relationships of primary platelet adhesion receptors mediating adhesion, activation and aggregation,...
Accumulating experimental evidence of stochasticity, self‐organization and abrupt non‐linear transitions underlying the dynamics of cellular structure and function is increasingly more consistent with the concepts and models of phase transitions, critical phenomena and non‐linear...
Rpb4 and Rpb7, are conserved subunits of RNA polymerase II that play important roles in stress responses such as growth at extreme temperatures, recovery from stationary phase, sporulation and pseudohyphal growth. Recent reports have shown that apart from stress response, these proteins also...
Human T cell leukemia virus type I (HTLV‐I) is the causative agent of a fatal malignancy known as adult T cell leukemia (ATL). The HTLV‐I Tax protein is thought to play a significant role in the initiation and pathogenesis of HTLV‐I‐mediated disease. Tax is a potent oncogene that...
Doxorubicin (trade name Adriamycin) is a widely used anticancer agent which exhibits good activity against a wide range of tumors. Although the major mode of action appears to be normally as a topoisomerase II poison, it also exhibits a number of other cellular responses, one of which is the...
Viruses have been invaluable tools for discovering key pathways of nucleocytoplasmic transport. Conversely, disruption of specific nuclear transport pathways, are crucial for the productive life cycle of some viruses. The major cellular mRNA export pathway, which uses TAP (NXF1)/p15(NXT) as...
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