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The flavanone naringenin (Nar), especially abundant in the Mediterranean diet, is reported to have anti‐proliferative effects in many cancer cell lines. Antioxidant activities, kinase and glucose uptake inhibition have been proposed as molecular mechanisms for these effects. In addition, an...
PPARs are a class of nuclear receptors involved in lipid and glucidic metabolism, immune regulation and cell differentiation. This spectrum of biological activities stimulated pharmacological research to synthetize different molecules with PPARs binding activity with beneficial therapeutic...
The activation and incorporation of selenium into selenocysteine containing selenoproteins has been well established in an Escherichia coli model system but there is little specific information concerning the transport and intracellular trafficking of selenium in biological systems in general. A...
In eukaryotes nearly 500 rRNAs, ribosomal proteins, snoRNAs and trans‐acting factors contribute to ribosome biogenesis. After more than 30 years of intense research, the incredible complexities of nucleolar function are revealed but details often remain unclear. Here we review this progress and...
The cell cycle controls processes of DNA replication and segregation of replicated DNA into two daughter cells. These processes are coordinated by multiple signaling pathways, which employ many protein kinases. The members of the family of Polo‐like protein kinases are among these key cell...
The actual cellular functions of the highly homologous small isoforms of the phosphatidylinositol transfer proteins, PI‐TPα and PI‐TPβ have been studied using many different experimental conditions varying from in vitro experiments with purified proteins and lipid vesicles to investigations...
Apoptotic cell death represents an important mechanism for the precise regulation of cell numbers, and a defense mechanism against tumor cells. Both bcl‐2 and mutant p53 gene products have been involved in apoptotic pathways. On the other hand, cell proliferation capacity and tumorgenesis have...
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