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One of the biggest surprises at the beginning of the 'post‐genome era' was the discovery of numerous genes encoding microRNAs. They were found in genomes of such diverse organisms as Caenorhabditis elegans, Drosophila melanogaster, Arabidopsis thaliana, and Homo sapiens which implies their...
In tuberculosis, oxidative stress is a result of tissue inflammation, poor dietary intake of micronutrients due to illness, free radical burst from activated macrophages, and anti‐tuberculosis drugs. These free radicals may in turn contribute towards pulmonary inflammation if not neutralized by...
Cytokines regulate many cellular responses such as proliferation, differentiation and survival and play regulatory roles in numerous organ systems. The cytokines of the IL‐6 family use the membrane glycoprotein gp130 as a signal transducer and signal through the JAK/STAT pathway. As they share...
Although it is employed in biological systems for intercellular signaling or inflammatory responses, nitric oxide is not readily contained by cell membranes and so might damage surrounding non‐target cells. We have studied the genetic and biochemical basis of cellular resistance to the toxicity...
Cancers have a clonal origin, yet their chromosomes and genes are non‐clonal or heterogeneous due to an inherent genomic instability. However, the cause of this genomic instability is still debated. One theory postulates that mutations in genes that are involved in DNA repair and in chromosome...
Cone snails have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in normal and diseased states. A number of...
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