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Previously, we have demonstrated that increased superoxide generation plays a role in the nitric oxide (NO)‐mediated inhibition of endothelial NO synthase (eNOS) in endothelial cells (ECs) and that the overexpression of SOD1 could reduce the inhibitory effect of NO. However, SOD1 overexpression...
The receptor‐regulated phospholipase C‐ β(PLC‐ β) signaling pathway is an important component in a network of signaling cascades that regulate cell function. PLC‐ βsignaling has been implicated in the regulation of cardiovascular function and neuronal plasticity. The G q family of G...
The relation between the energies of ion movement and ATP hydrolysis is unknown in tissues with widely varying electric potentials. Consequently, we measured the concentration of the nine major inorganic ions in the extra‐ and intracellular phases in heart, liver, and red cells with resting...
Nitric oxide (NO) is an important biological messenger in the regulation of tissue homeostasis and pathophysiological processes. Here, we investigated the effect of NO on gastric mucus glycoprotein (mucin) synthesis, apoptotic processes, and the involvement of extracellular signal‐regulated...
The inhibitor of apoptosis (IAP) gene family prevents cell death by binding to and inhibiting caspases. In addition to negatively regulating apoptosis, IAPs bind to signaling intermediates and receptors, and participate in diverse cellular functions. Here, we describe the physiological functions...
p ‐Aminobenzamidine inhibits competitively the catalytic activity of enzymes that recognize preferentially the L ‐arginyl side chain and related structures. Notably, p ‐aminobenzamidine is considered as the prototype of trypsin‐like serine protease inhibitors. Furthermore, p...
We investigated signaling pathways leading to tumor necrosis factor (TNF) α‐induced intercellular adhesion molecule (ICAM)‐1 and vascular cell adhesion molecule (VCAM)‐1 expression in chondrosarcoma cells, and determined the functional significance of their expression by examining Jurkat T...
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