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This brief review outlines some of the most relevant proteins of the Z‐disc and the complex network of interactions that link them together in a stable structure. Apart from the well‐known Z‐disc proteins such as actin, cap‐Z, titin, nebulin, and α‐actinin 2, several other Z‐disc...
The animal model of H. pylori lipopolysaccharide (LPS)‐induced gastritis was used to study the role of extracellular signal‐regulated kinase (ERK) and p38 mitogen‐activated protein kinase (MAPK) in the mucosal release of tumor necrosis factor‐ α (TNF‐ α) and endothelin‐1 (ET‐1) in...
A transactivation motif has been identified in the neurodegenerative disease protein, CLN3. The C‐terminal domain (residues 394‐438) of CLN3 can function as a transcriptional activator when fused to the DNA binding domain, LexA. A series of deletion and substitution constructs have been...
Toelucidate genomic organization of BmTXK βand BmTXKS2, two scorpion venom peptides from Chinese scorpion Buthus martensii Karsch(BmK) were first isolated and their genomic regions characterized using the PCR method. Analysis of nucleotide sequence shows that there exists different intron...
Initiation of protein biosynthesis is an essential process occurring in cells throughout the three phylogenetic domains, Bacteria, Archaea, and Eucarya. IF1/eIF1A and IF2/eIF5B, two conserved translation initiation factors are involved in this important step of protein biosynthesis. The...
Insulin stimulates glucose uptake in association with phosphatidylinositol (PI) 3‐kinase activation mechanisms in rat adipocytes. Insulin stimulated glucose uptake to 6.5‐fold, and 12‐ o ‐tetradecanoyl phorbol 13‐acetate (TPA) also stimulated glucose uptake to 4.5‐fold in rat...
Influence of H 2 O 2 on glycolysis was investigated. A hypothesis previously formulated was tested according to which a mild oxidation of glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) results in uncoupling of oxidation and phosphorylation at this step of glycolysis due to acylphosphatase...
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