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Malaria parasites proliferate asexually within the vertebrate host but must undergo sexual reproduction for transmission to mosquitoes and hence infection of new hosts. The developmental pathways controlling gametocytogenesis are not known, but several protein kinases and other putative signal...
All cells have developed various mechanisms to regulate precisely the availability of important micronutrients such as zinc and copper; in many cells, this regulation is mediated by P‐type ATPases. Most of the P1‐ATPases have been described very recently, and little is known about their...
Single‐chain insulin/IGF‐1 hybrid‐(Ins/IGF‐1(C)), single‐chain porcine insulin precursor‐(PIP), and B10Asp PIP were prepared by protein engineering. Their growth‐promoting activities in mouse breast cancer cell line GR2H6 are 10, 0.2, and 2 times that of insulin, respectively, and...
The effect of streptozotocin‐induced diabetes on cholinesterases activities was studied in the retina and, for comparison, in other nervous and nonnervous tissues. Streptozotocin diabetes did not affect acetylcholinesterase activity in the retina but increased its activity in the cerebral...
Investigation of the protein product of the oestrogen‐regulated gene LIV‐1, implicated in metastatic breast cancer, has revealed 10 protein sequences of unknown function that belong to a new family with potential to control intracellular Zn2+ homeostasis. Sequence alignment highlights the...
The exchange of mass, energy, and information with the environment typical of open systems can also be found in enzymes. An enzyme is able to receive information on substrate concentration in an arbitrary concentration range. This actually follows from the elementary solution of...
A ribonuclease from cobra snake venom was isolated and purified to homogeneity using antibody‐affinity chromatography, increasing the yield fourfold. The purified enzyme showed cytidylic acid specificity, as reported earlier. Further, the effects of temperature, pH, metal ions, inhibitors, and...
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