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There is accumulating evidence that caspase-independent programs play a significant role in delayed neuronal death following ischemic stroke. Previous research has implicated mitochondrial proteins, such as apoptosis-inducing factor (AIF) and Bcl-2/adenovirus E1B 19 kDa-interacting protein...
Introduction : Patent ductus arteriosus (PDA) ligation can lead to postoperative hemodynamic instability requiring inotropic support, termed hemodynamic decompensation. The purpose of this study was to prospectively determine the incidence, predictors, and clinical impact of hemodynamic...
The use of fresh osteochondral allografts is a popular approach to treat articular cartilage lesions. Immunological reactions of the recipient elicited by the allograft's osseous portion, however, frequently result in their deterioration. So far, little emphasis has been put on describing...
Ischemia-reperfusion injury (IRI) to the lower extremities causes both local damage and serious dysfunction to remote organs, including lungs and kidneys. However, effective therapies are not available. This study aims to determine if simvastatin reduced the severity of remote damage following...
Brain edema secondary to increased blood–brain barrier (BBB) permeability is a lethal complication in fulminant hepatic failure (FHF). Intact tight junctions (TJ) between brain capillary endothelial cells are critical for normal BBB function. However, the role of TJ in FHF has not been...
Harvey Cushing (1869–1939) is considered one of the great surgical innovators of his generation. His strong determination, self-driven attitude, intense desire to succeed, and clear intellect aided him in his ascent to the top of a new field of medicine, neurosurgery. His innovative force is...
This study evaluates the effectiveness of direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX therapy) on warm ischemia-reperfusion injury of the lung using a canine mode. Materials and Methods : Ten adult mongrel dogs weighing 13–16 kg were used. After a left thoracotomy,...
Good men represent a prime example to follow by surgeons and other professionals. Good men produce good deeds and good deeds are the essence of a good life. Surgeons are frequently good men accountable for good deeds. Good men are not always part of the surgical profession. Efforts should be...
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