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A technique of bile diversion by tube choledochoureterostomy has been devised for the purpose of studying the role of bile in the intestinal absorption of drugs. This method was used in six dogs. No technical difficulties or major complications developed, as are inevitable with alternative...
A randomized blind prospective study was carried out to determine if an anabolic androgenic steroid with a high anabolic/androgenic ratio, Group A, (1/0.05) methenolone enanthate (me), compared to an anabolic/androgenic agent with a low anabolic/androgenic ratio, Group B, (1.0/1.0) testosterone...
The sequence of acute ischemia, reperfusion, and elevated tissue pressure, with subsequent neuromuscular damage, results in the clinical entity known as the compartment syndrome. We have developed a canine hindlimb model that successfully replicates these clinical features. Surgical...
Over 50,000 artificial grafts are implanted every year in the United States. Present surgical procedures require either bypass or clamping off of the vessel to be replaced. Complications of these techniques include aneurysms and left ventricular overload. In addition, for aortic procedures...
In ischemic canine kidneys protected by Bretschneider's HTK solution the glycolytic lactate production is limited by a low renal substrate content. However, for anaerobic energy supply ischemic organs depend on glycolysis. To evaluate the role of glycolysis in renal protection, the relationship...
Warfarin sodium (Coumadin) has been used as an effective anti-coagulating agent in human medicine for many years, although careful monitoring of its effects are necessary to avoid excessive anticoagulation. Previous experience with this drug for chronic anticoagulation therapy in miniature swine...
To study the effects of chronic bile reflux on the mammalian gastric mucosa, the ferret model was chosen for its practical aptitude and for its similarity to human gastric anatomy and physiology. A technique was first perfected for endoscopically directed gastric mucosal biopsy in the ferret....
Following right ventriculotomy, Gore-Tex PTFE vascular grafts were placed in eight neutered male, 6- to 8-week-old, 8- to 12-kg pigs. Ten to 14 months after surgery each pig was evaluated by right heart catheterization. The swine were sacrificed and the hearts were evaluated grossly and...
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