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Background and purpose The use of intensity-modulated radiotherapy (IMRT) is now widely advocated for the treatment of head-and-neck cancers, to increase the therapeutic ratio of radiotherapy used as sole modality of treatment or in combination with chemotherapy. This report aims to summarize the...
Purpose Normal tissue toxicity remains a dose limitation for cancer radiotherapy and chemoradiotherapy. Growth factors offer a novel means of mitigating normal tissue radiotoxicity. In particular, keratinocyte growth factor (rHuKGF), whose proliferative activity is restricted to epithelial cells,...