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Purpose : Ophthalmologic examinations were conducted on atomic bomb (A‐bomb) survivors 55 years after exposure. Materials and methods : A‐bomb survivors who had been exposed before 13 years of age at the time of the bombings in 1945 or who had been examined in a previous study between 1978...
Purpose : A key enzyme of polyamine catabolism, spermidine/spermine N 1 ‐acetyltransferase (SSAT), is responsive to antiproliferative agents. The role of SSAT in cellular responses to X‐ray irradiation was examined. Materials and methods : Exponentially growing HeLa S3 cells were irradiated...
Purpose : Because of the crucial practical importance of acute radiation exposure associated with combined injuries, the study was undertaken to investigate the effect of various doses of ascorbic acid on the survival and healing of wounds in mice exposed to whole‐body γ ‐radiation....
Purpose : To examine whether X‐rays induce sister chromatid exchanges (SCE). Materials and methods : Peripheral lymphocytes irradiated in vitro or in vivo were cultured and treated with okadaic acid to generate premature chromosome condensation (PCC). When identical spreads were analysed using...
Estimates of radiation‐induced malignancies come principally from the atomic (A)‐bomb survivors and show an excess incidence of carcinomas that is linearly related to dose from about 5 cGy to 2.5 Gy. Above and below this dose range there is considerable uncertainty about the shape of the...
Purpose : Telomere shortening has been proposed to trigger senescence, and since most primary cells do not express active telomerase, reactivation of telomerase activity was proposed as a safe and non‐transforming way of immortalizing cells. However, to study radiation responses, it is as yet...
Purpose : To study the formation of the dihydrothymine lesion produced in DNA by ionizing radiation in an anaerobic environment. Materials and methods : The dihydrothymine lesion, along with other lesions, was isolated from an X‐irradiated aqueous solution of the dinucleoside monophosphate...
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