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Summary Measurements have been made of the inactivation of the metallo-enzyme dihydro-oratic dehydrogenase in solution by characteristic X-rays at energies above and below the K absorption edge of the constituent iron atom. From the dose–survival curves and knowledge of the equilibrium electron...
Summary The transfer of soluble Np(V) nitrate was measured in gastrointestinal segments from adult rats by two procedures: ( a ) instillation, in segments in which the physico-chemical form of Np might be modified by gastrointestinal factors; and ( b ) perfusion, in segments in which the luminal...
Summary Three different cell lines, Ehrlich ascites tumour (EAT) cells, HeLa S 3 cells and LM mouse fibroblasts, were used to investigate whether or not the extent of heat killing (44°C) and heat radio-sensitization (44°C before 0–6 Gy X-irradiation) are related. Although HeLa cells were the...
Summary To elucidate the characteristics of the action of tritium β-rays, the following parameters are derived: ( a ) electron slowing down spectra of primary electrons (β-rays) and δ-rays in a medium containing tritiated water; and ( b ) frequency distributions for the microdosimetric...
Summary The proliferation of human blood lymphocytes from ageing donors, responding to concanavalin A, showed greater sensitivity to inhibition by X-rays than similar cells from younger donors. This increased sensitivity was associated with deficiency in repair of X-ray-induced damage to nuclear...
Summary Clonogenic survival assays after γ-radiation in vitro were performed on freshly isolated and subcultured keratinocytes from mouse skin, mouse tongue and human skin. Survival curves were constructed by fitting the data to a multi-target model of cell survival. When subcultured,...
Summary A pulse radiolysis study of glutathione in aqueous solution at pH 5·5 containing N 2 O/O 2 mixtures at various ratios indicates that oxygen rapidly adds to the thiyl glutathione radical yielding a transient absorption, with a maximum at 540 nm, whose characteristics appear to be...
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