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Graphical abstract . The solid dispersions using the mixture of Solutol® HS15 and HPMC 2910 appeared to be effective to improve the dissolution and oral exposure of biochanin A.
A 3D-QSPkR methodology using self organizing molecular field analysis was employed to rationalize the pharmacokinetic properties in order to obtain an insight for the generation of novel molecular architecture of quinolones with optimal half life and improved biological profile.
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