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Graphical abstract . The solid dispersions using the mixture of Solutol® HS15 and HPMC 2910 appeared to be effective to improve the dissolution and oral exposure of biochanin A.
Representative visual inspection of the aqueous copolymer system at 15 °C (A), 20 °C (B), 25 °C (C), 30 °C (D), and 35 °C (E) (left to right: PF127 (20%), alginate and PF127 blending (A + P, 20% + 0.63%), and the alginate–Pluronic F127 composite copolymer (AP, 15%)).
A 3D-QSPkR methodology using self organizing molecular field analysis was employed to rationalize the pharmacokinetic properties in order to obtain an insight for the generation of novel molecular architecture of quinolones with optimal half life and improved biological profile.
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