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Stability studies of 2-hydroxymethyl-4,8-dibenzo(1,2- b :5,4- b ′)dithiophene-4,8-dione (NSC 656240, dithiophene), a poorly water-soluble (∼5 μg/ml) potential anticancer drug are reported. Dithiophene stability turned out to be very sensitive to laboratory fluorescent lighting. The rate of...
The influence of subcoat application and micro-environmental pH on the dissolution properties of enteric coated sodium valproate pellets was investigated. The pellets were prepared by solution-layering or wet-mass extrusion-spheronization methods. In order to pass the USP enteric test, the...
Mucoadhesive patches containing 10 mg miconazole nitrate were evaluated. The patches were prepared with ionic polymers, sodium carboxymethyl cellulose (SCMC) and chitosan, or non-ionic polymers, polyvinyl alcohol (PVA), hydroxyethyl cellulose (HEC) and hydroxypropylmethyl cellulose (HPMC)....
Buspirone hydrochloride (BH) is a structurally and pharmacologically unique anxiolytic that is used to treat a variety of different anxiety conditions. The marketed product is named BuSpar ® . The in vitro iontophoretic delivery of BH through human skin was investigated in order to evaluate the...
Levothyroxine tablets, 50 μg, have been marketed for many decades but have had numerous recalls due to degradation and failure to meet potency. These experiments were devised to study the effects of various excipients on the stability of levothyroxine sodium pentahydrate in aqueous slurries and...
The combined effect of cosolvent (methanol (MeOH), ethanol (EtOH), or n -propanol ( n -PrOH)) and complexant hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility of Fluasterone is evaluated and explained with a simple equation. The calculated constants in the equation not only quantitatively...
Gelatin microparticles containing propolis extractive solution (PES) were prepared by spray-drying technique. The optimization of the spray-drying operating conditions and the proportions of gelatin and mannitol were investigated. Regular particle morphology was obtained when mannitol was used,...
The development of parenteral solution dosage forms of interferon α 2 (rhIFN-α2) without human albumin may significantly diminish the problem of forming highly immunogenic rhIFN-α2b aggregates and the potential risk of blood-transmitted diseases caused by infectious viruses and often living...
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