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Elementary osmotic pumps releasing solutions of active materials at a controlled rate have increased in popularity during the last two decades. In this study, the effect of the delivery orifices and the concentration of osmotic agents on the rate of release of the active material was...
The coating of nearly spherical porous alumina with a mean diameter, d P , of 3.9 mm, with a suspension of sucrose and talc in water, was carried out in a conical-cylindrical spouted bed. The rate of increase in particle mass, K 1 , and the mass fraction of atomized solids incorporated by the...
The melting and crystallisation behaviour of paracetamol dispersions in polyethylene glycol (PEG) 4000 has been studied using differential interference contrast microscopy fitted with a hot stage. The effects of thermally cycling physical mixes of the two components have been studied with...
A new stable amphotericin B nanosphere-based delivery system was obtained by a solvent displacement process. A reproducible and monodisperse size distribution centered on 220 nm was obtained, when AmB and poly(ε-caprolacton) were dissolved in an appropriate solvent mixture. UV-Visible and...
W/O/W multiple emulsions composed of medium-chain triglycerides containing insulin with aprotinin, a protease inhibitor, and/or sodium taurocholate, an absorption enhancer, were prepared by a two-step emulsification method at 15°C. Whatever the nature of the substance introduced in the internal...
Interactions between acetylated and amidated pectins and different drugs were studied using affinity capillary electrophoresis (ACE). It is shown that ACE is a suitable method to characterize these interactions at the molecular level. Calculating the equilibrium binding constants it was found...
The physicochemical properties of theophylline monohydrate and anhydrous polymorphic form II were evaluated using crystallographic, calorimetric and computational methods. The heats of solution of theophylline monohydrate and its anhydrous form were 28.6 and 19.4 kJ/mol, respectively, and the...
Polystyrene nanoparticles having poly(N-isopropylacrylamide) branches on their surfaces (PNIPAAm nanoparticles) were synthesized and various attempts were made in rats to increase the absorption enhancement of orally administered salmon calcitonin (sCT) by these nanoparticles. The hypocalcemic...
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