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The effect on mucociliary transport velocity (MTV) of 0.25% solutions of five different types of chitosan, with varying molecular weights and degrees of deacetylation, was evaluated using the frog palate model. The MTV was determined by monitoring the speed of movement of graphite particles...
A new method was evaluated to determine the solubility of some sparingly soluble materials, using a Coulter counter TA II. This method was based on characterizing the remaining undissolved amount of the suspended material for different initial amounts added, after a specific agitation time. The...
The phase separation behavior of two nonionic surfactants, polyoxyethylene (10) oleyl ether (I) and polyoxyethylene (10) cetyl ether (II), was examined in solutions containing polyethylene glycols (PEGs) of various molecular weights. It was found that PEGs decrease the cloud points of both...
There are many ongoing investigations to improve the nasal bioavailability of peptide and protein formulations. The presence of bioadhesive polymers in nasal formulations may increase the residence time of the drugs in the nasal cavity. A combination of bioadhesive polymers with permeation...
The diffusion of ethanol into and through soft gelatin films analogous to capsule shell formulations during the drying process has been investigated using a specially designed diffusion cell. Using microcomputer-controlled sampling, it was possible to monitor the diffusion through films at...
Covalent conjugates of alginate and the antitumour agent daunomycin (DNM) were synthesized to be stable in the circulation and allow release of the drug in the acidic milieu of the endosomal and lysosomal compartments of tumour cells or the slightly acidic extracellular fluid of some solid...
Differential scanning calorimetry (DSC) data, in conjunction with Fourier transform infrared (FTIR) spectroscopy and X-ray powder diffraction (XRPD), was used to discriminate various polymorphic forms of zanoterone. The solid-state degradation rate of form IV (hemihydrate A) was found to be...
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